In a podcast episode of the Australian Broadcast Corporation podcast, “All In the Mind,” the hosts delve into the intriguing science of mind over body, specifically focusing on the placebo and nocebo effects.

What, though, are the molecular underpinnings of the placebo phenomenon, and the neuronal networks that wield such a remarkable influence over a wide array of behaviors.

While the placebo effect often takes center stage, a less-discussed phenomenon is the nocebo effect. It’s an intriguing concept, where negative expectations can yield adverse consequences, mirroring the power of positive expectations in the placebo phenomenon.

What roles do prior expectations play and what are the brain regions associated with this captivating phenomenon? What brain regions are implicated in this widespread capability to influence various experiences and behaviors, including pain sensation and motor function? Could it be that specific brain regions associated with expectations recruit projecting areas that, in turn, release “placebo” neurotransmitters or modulators?

Are there people that are not affected by the placebo effect? Are there people with certain brain injuries that render them impervious to the placebo affect?

Also of note, psychological stress can accelerate the shortening of telomeres, a process associated with aging. It’s a fascinating connection between the mind and the body, highlighting the profound impact our mental states can have on our overall well-being.

Original draft written in March 2017